BernheimV1, Main, Exploration, bibRecord, 000002

Constitutive calcium entry and cancer: updated views and insights.

Identifieur interne : 000002 ( Main/Exploration ); précédent : 000001; suivant : 000003

Constitutive calcium entry and cancer: updated views and insights.

Auteurs : Olivier Mignen [France] ; Bruno Constantin [France] ; Marie Potier-Cartereau [France] ; Aubin Penna [France] ; Mathieu Gautier [France] ; Maxime Guéguinou [France] ; Yves Renaudineau [France] ; Kenji Shoji [France] ; Romain Félix [France] ; Elsa Bayet [France] ; Paul Buscaglia [France] ; Marjolaine Debant ; Aurélie Chantôme [France] ; Christophe Vandier [France]

Source :

European Biophysics Journal [ 0175-7571 ] ; 2017-05-17.

RBID : Hal:inserm-01526286

Abstract

Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane Ca2+ channels including store-operated Ca2+ channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca2+ channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca2+ channels contributes to Ca2+ entry and the transient increase in cytosolic Ca2+ concentration involved in intracellular signaling. However, in various experimental conditions, Ca2+ entry and/or Ca2+ currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca2+ channels are already open/activated in basal condition, contributing therefore to constitutive Ca2+ entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.

Url:

http://www.hal.inserm.fr/inserm-01526286

DOI: 10.1007/s00249-017-1216-8

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Bayet, Elsa" sort="Bayet, Elsa" uniqKey="Bayet E" first="Elsa" last="Bayet">Elsa Bayet</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-507100" status="INCOMING">          <orgName>Network “Ion channels and Cancer-Canceropole Grand Ouest” [Nantes]</orgName>
          <orgName type="acronym">IC-CGO</orgName>
          <desc>            <address>              <addrLine>Maison de la Recherche en Santé - 63, quai Magellan 44000 Nantes.</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
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        <tutelles><tutelle active="#struct-507099" type="direct"><org type="institution" xml:id="struct-507099" status="INCOMING">          <orgName> Cancéropôle Grand-Ouest [Bretagne-Centre-Pays de Loire]</orgName>
          <desc>            <address>              <addrLine>Maison de la Recherche en Santé - 63, quai Magellan 44000 Nantes.</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Buscaglia, Paul" sort="Buscaglia, Paul" uniqKey="Buscaglia P" first="Paul" last="Buscaglia">Paul Buscaglia</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182183" status="VALID">          <idno type="RNSR">201220082F</idno>
          <orgName>Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)</orgName>
          <desc>            <address>              <addrLine>EFS Bretagne, 46 rue Félix le Dantec 29218 Brest Cedex 2</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-brest.fr/umr1078/</ref>
          </desc>
          <listRelation>            <relation active="#struct-300164" type="direct"></relation>
            <relation active="#struct-300314" type="direct"></relation>
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          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300314" type="direct"><org type="institution" xml:id="struct-300314" status="VALID">          <orgName>Université de Brest</orgName>
          <orgName type="acronym">UBO</orgName>
          <desc>            <address>              <addrLine>Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-brest.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U1078" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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          </desc>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Debant, Marjolaine" sort="Debant, Marjolaine" uniqKey="Debant M" first="Marjolaine" last="Debant">Marjolaine Debant</name>
<affiliation><hal:affiliation type="researchteam" xml:id="struct-507098" status="VALID">          <orgName> Immunologie et Pathologie</orgName>
          <orgName type="acronym">EA 2216</orgName>
          <desc>            <address>              <addrLine>5 Foch - CHU Morvan - BP 824 - 29609 Brest.</addrLine>
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          </desc>
          <listRelation>            <relation name="EA 2216" active="#struct-300314" type="direct"></relation>
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          <orgName type="acronym">UBO</orgName>
          <desc>            <address>              <addrLine>Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest</addrLine>
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</tutelle>
<tutelle name="ESPRI-ERI 29" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
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            <ref type="url">http://www.inserm.fr</ref>
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        </org>
</tutelle>
</tutelles>
</hal:affiliation>
</affiliation>
</author>
<author><name sortKey="Chantome, Aurelie" sort="Chantome, Aurelie" uniqKey="Chantome A" first="Aurélie" last="Chantôme">Aurélie Chantôme</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-507100" status="INCOMING">          <orgName>Network “Ion channels and Cancer-Canceropole Grand Ouest” [Nantes]</orgName>
          <orgName type="acronym">IC-CGO</orgName>
          <desc>            <address>              <addrLine>Maison de la Recherche en Santé - 63, quai Magellan 44000 Nantes.</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-507099" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-507099" type="direct"><org type="institution" xml:id="struct-507099" status="INCOMING">          <orgName> Cancéropôle Grand-Ouest [Bretagne-Centre-Pays de Loire]</orgName>
          <desc>            <address>              <addrLine>Maison de la Recherche en Santé - 63, quai Magellan 44000 Nantes.</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vandier, Christophe" sort="Vandier, Christophe" uniqKey="Vandier C" first="Christophe" last="Vandier">Christophe Vandier</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-507100" status="INCOMING">          <orgName>Network “Ion channels and Cancer-Canceropole Grand Ouest” [Nantes]</orgName>
          <orgName type="acronym">IC-CGO</orgName>
          <desc>            <address>              <addrLine>Maison de la Recherche en Santé - 63, quai Magellan 44000 Nantes.</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-507099" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-507099" type="direct"><org type="institution" xml:id="struct-507099" status="INCOMING">          <orgName> Cancéropôle Grand-Ouest [Bretagne-Centre-Pays de Loire]</orgName>
          <desc>            <address>              <addrLine>Maison de la Recherche en Santé - 63, quai Magellan 44000 Nantes.</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1007/s00249-017-1216-8</idno>
<series><title level="j">European Biophysics Journal</title>
<idno type="ISSN">0175-7571</idno>
<imprint><date type="datePub">2017-05-17</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane Ca2+ channels including store-operated Ca2+ channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca2+ channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca2+ channels contributes to Ca2+ entry and the transient increase in cytosolic Ca2+ concentration involved in intracellular signaling. However, in various experimental conditions, Ca2+ entry and/or Ca2+ currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca2+ channels are already open/activated in basal condition, contributing therefore to constitutive Ca2+ entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Centre-Val de Loire</li>
<li>Pays de la Loire</li>
<li>Poitou-Charentes</li>
<li>Région Bretagne</li>
<li>Région Centre</li>
</region>
<settlement><li>Angers</li>
<li>Poitiers</li>
<li>Rennes</li>
<li>Tours</li>
</settlement>
<orgName><li>Centre Val de Loire Université</li>
<li>Université François-Rabelais de Tours</li>
<li>Université d'Angers</li>
<li>Université de Poitiers</li>
<li>Université de Rennes 1</li>
<li>Université européenne de Bretagne</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Debant, Marjolaine" sort="Debant, Marjolaine" uniqKey="Debant M" first="Marjolaine" last="Debant">Marjolaine Debant</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Mignen, Olivier" sort="Mignen, Olivier" uniqKey="Mignen O" first="Olivier" last="Mignen">Olivier Mignen</name>
</noRegion>
<name sortKey="Bayet, Elsa" sort="Bayet, Elsa" uniqKey="Bayet E" first="Elsa" last="Bayet">Elsa Bayet</name>
<name sortKey="Buscaglia, Paul" sort="Buscaglia, Paul" uniqKey="Buscaglia P" first="Paul" last="Buscaglia">Paul Buscaglia</name>
<name sortKey="Chantome, Aurelie" sort="Chantome, Aurelie" uniqKey="Chantome A" first="Aurélie" last="Chantôme">Aurélie Chantôme</name>
<name sortKey="Constantin, Bruno" sort="Constantin, Bruno" uniqKey="Constantin B" first="Bruno" last="Constantin">Bruno Constantin</name>
<name sortKey="Felix, Romain" sort="Felix, Romain" uniqKey="Felix R" first="Romain" last="Félix">Romain Félix</name>
<name sortKey="Gautier, Mathieu" sort="Gautier, Mathieu" uniqKey="Gautier M" first="Mathieu" last="Gautier">Mathieu Gautier</name>
<name sortKey="Gueguinou, Maxime" sort="Gueguinou, Maxime" uniqKey="Gueguinou M" first="Maxime" last="Guéguinou">Maxime Guéguinou</name>
<name sortKey="Penna, Aubin" sort="Penna, Aubin" uniqKey="Penna A" first="Aubin" last="Penna">Aubin Penna</name>
<name sortKey="Potier Cartereau, Marie" sort="Potier Cartereau, Marie" uniqKey="Potier Cartereau M" first="Marie" last="Potier-Cartereau">Marie Potier-Cartereau</name>
<name sortKey="Renaudineau, Yves" sort="Renaudineau, Yves" uniqKey="Renaudineau Y" first="Yves" last="Renaudineau">Yves Renaudineau</name>
<name sortKey="Shoji, Kenji" sort="Shoji, Kenji" uniqKey="Shoji K" first="Kenji" last="Shoji">Kenji Shoji</name>
<name sortKey="Vandier, Christophe" sort="Vandier, Christophe" uniqKey="Vandier C" first="Christophe" last="Vandier">Christophe Vandier</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration Hippolyte Bernheim

Constitutive calcium entry and cancer: updated views and insights.

Constitutive calcium entry and cancer: updated views and insights.

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